Common microRNAs Target Established ASD Genes
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چکیده
منابع مشابه
Common microRNAs Target Established ASD Genes
COMPLEX GENETIC ARCHITECTURE IN AUTISM Autism spectrum disorder (ASD) encompasses a range of early-onset neurodevelopmental disorders characterized by impaired social interactions and communications, together with repetitive stereotypic behaviors (MIM20895; DSM5). Individuals with ASD can display a broad clinical profile ranging in symptom severity and comorbidities. A strong genetic component ...
متن کاملMicroRNAs that target RGS5
Objective(s):An earlier meta-analysis on gene expression data derived from four microarray, two cDNA library, and one SAGE experiment had identified RGS5 as one of only ten non-housekeeping genes that were reported to be expressed in human trabecular meshwork (TM) cells by all studies. RGS5 encodes regulator of G-protein signaling-5. The TM tissue is the route of aqueous fluid outflow, and is r...
متن کاملP127: The Role of Genes in ASD
Autism Spectrum Disorder (ASD) is a heterogeneous group of neurological disorders that is determined solely by their behavior. In this disease, a large part of the neurological disorder and neural controls disorder are observed. Researchers believe that over expressions changes in many genes are the cause of autism. Our goal is to investigate the genetic factors affecting ASD and its treatment ...
متن کاملmicrornas that target rgs5
objective(s):an earlier meta-analysis on gene expression data derived from four microarray, two cdna library, and one sage experiment had identified rgs5 as one of only ten non-housekeeping genes that were reported to be expressed in human trabecular meshwork (tm) cells by all studies. rgs5 encodes regulator of g-protein signaling-5. the tm tissue is the route of aqueous fluid outflow, and is r...
متن کاملPrediction of regulatory modules comprising microRNAs and target genes
MOTIVATION MicroRNAs (miRNAs) are small endogenous RNAs that can play important regulatory roles via the RNA-interference pathway by targeting mRNAs for cleavage or translational repression. We propose a computational method to predict miRNA regulatory modules (MRMs) or groups of miRNAs and target genes that are believed to participate cooperatively in post-transcriptional gene regulation. RE...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2014
ISSN: 1664-2295
DOI: 10.3389/fneur.2014.00205